Everyone is going to be dissecting this trailer to death, but here's what I think: Season 6 looks like it's going to be all about vengeance, and that suits me just fine.
I don't think we're going to know for sure if Jon is dead or not. I think this season is going to be treated like the last season that didn't have Bran. We get Bran back, but lose Jon. There's definitely yet another civil war that's going to open up between Cercei and the religious extremists who trounced her last season.
As for Daenerys, we don't get much about her from the trailer. From what it looks like, she could be someone's prisoner, or even become a slave herself but there's no telling. We also don't get much on what's happening with Arya or Sansa (although it definitely shows Sansa joining the game).
All in all, the trailer seemed like a lot of flashy imagery to get us excited for the season. First episode airs on April 24th.
By the by, if you're anything like me, I really dug the cover of "Wicked Game" by James Vincent McMorrow. Check out the whole song below if you like!